Partial Molar Pregnancy with Diploid Chromosomal Structure
Keywords:
Diploid Chromosome, HELLP syndrome, Partial Molar Pregnancy, Triploid ChromosomeAbstract
Molar pregnancy is characterized by abnormal trophoblast proliferation and gestational trophoblastic neoplasms are included in the differential diagnosis. There are two types; complete and partial moles. Chromosome structure is generally diploid in the complete mole and triploid in the partial mole. Molar pregnancy recurs around 1%. Genetic mutations that can cause the disease have been identified. This report presents the management of a partial mole who had two previous molar pregnancies and whose current pregnancy was complicated by HELLP syndrome. The diploid fetal chromosome structure of the case with clinically partial mole features made the case more interesting.
References
Abi Nahed R, Elkhoury Mikhael M, Reynaud D, et al. Role of NLRP7 in Normal and Malignant Trophoblast Cells. Biomedicines. 2022;10(2):252.
Al Ghadeer HA, Al Kishi N, Algurini KH, et al. Partial Molar Pregnancy With Normal Karyotype. Cureus. 2022;14(10):e30934.
Berkowitz RS, Goldstein DP. Current advances in the management of gestational trophoblastic disease. Gynecol Oncol. 2013;128(1):3-5.
Bruce S, Sorosky J. Gestational Trophoblastic Disease. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.
Fatemi N, Varkiani M, Ramazanali F, Almadani N, Totonchi M. A familial case of recurrent hydatidiform mole with p.Asp108Ilefs∗30 causing mutation in KHDC3L: A genetic and clinical report.
Taiwan J Obstet Gynecol. 2022;61(2):395-398. doi: 10.1016/j.tjog.2022.02.038.
Garg P, Dhingra H. Recurrent hydatidiform mole in nine consecutive pregnancies: a rare case report from India. J Obstet Gynaecol. 2022;42(1):175-176.
Ghassemzadeh S, Farci F, Kang M. Hydatidiform Mole. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.; 2022.
Kirkpatrick CA. The HELLP syndrome. Acta Clin Belg. 2010;65(2):91-97. doi: 10.1179/acb.2010.020.
Lin LH, Maestá I, Braga A, et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol. 2017;145(1):88-95.
Ngan HYS, Seckl MJ, Berkowitz RS, et al. Diagnosis and management of gestational trophoblastic disease: 2021 update. Int J Gynaecol Obstet. 2021;155(S1):86-93.
Ning F, Hou H, Morse AN, Lash GE. Understanding and management of gestational trophoblastic disease. F1000Res. 2019;8.
Rahamni M, Parviz S. A case report of partial molar pregnancy associated with a normal appearing dizygotic fetus. Asian Pac J Reprod. 2016;5(2):171-173.
Rezaei M, Suresh B, Bereke E, et al. Novel pathogenic variants in NLRP7, NLRP5, and PADI6 in patients with recurrent hydatidiform moles and reproductive failure. Clin Genet. 2021;99(6):823-828. doi: 10.1111/cge.13941.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM. Choriocarcinoma in Women: Analysis of a Case Series With Genotyping. Am J Surg Pathol. 2017;41(12):1593-1606. doi: 10.1097/pas.0000000000000937.
Sebire NJ. Recurrent GTD and GTD coexisting with normal twin pregnancy. Best Pract Res Clin Obstet Gynaecol. 2021;74:122-130. doi: 10.1016/j.bpobgyn.2020.12.002.
